The Anna Ranch Heritage Center, a National Historic Site, was in the same ranching family for five generations. It is still a working ranch, and shares the story of a remarkable woman in ranching, Anna Lindsey Perry-Fiske, who was known as "The First Lady of Ranching" in Hawaii. The ranch was founded by Anna's great, great grandfather James Fay who was a contemporary of John Palmer Parker, the founder of Parker Ranch. The ranch house has been maintained and restored for its historic character and contains a significant archive collection of records, photographs, maps, artifacts, and household items that tell a story of Waimea's past, and the rich history of ranching on Hawaii island.

The East Hawaii Cultural Center (EHCC) is a cultural center in Hilo, Hawaii, that has regular art exhibits and holds workshops and classes. Administered by the East Hawaii Cultural Council, an umbrella group of local arts organizations, the Center is housed in a historic former police station facing Kalakaua Park.

On the waterfront in historical Kailua-Kona, Hulihe‘e Palace was built in 1838 as a home for High Chief Kuakini, governor of the island of Hawai‘i. Today, it has been restored and furnished to reflect the lifestyle of the Hawaiian royalty in the late 1800s.

'Imiloa Astronomy Center weaves together Hawaii's cultural heritage with today‚s newest astronomy findings into a compelling story of star exploration. The center incorporates both Hawaiian and English languages to enhance the cultural and learning experience. Interactive and compelling exhibits, including two small exhibit theaters, and high-tech planetarium reveal stories of the Kumulipo, Hawaiian stories of origins, combined with origins and journeys of exploration by astronomers. Here, science and culture join together to inspire and offer a new perspective of seeing the world.

Laupahoehoe Train Museum and Visitor Center Located on highway 19, near mile marker 25 (look for the brown Hilo-Hamakua Heritage Coast signs and the railroad crossing signs in the front lawn). There's more than meets the eye. Housed in a beautifully restored railroad employee home, on the site of the old Laupahoehoe Train Station, furnished in the period of the early 1900’s. Public restrooms and Gift Shop available; on-going engine and caboose restorations on track.

A lesson in both cultural and natural history of Hawai‘i, the restored home of missionaries David and Sarah Lyman, built in 1839, houses Hawaiian, missionary and ethnic artifacts, volcano and mineral displays, flora and fauna, marine and land shells. Collections include Chinese and Hawaiian art, and features paintings and prints on the subject of Hawai‘i.

The Onizuka Center for International Astronomy, also known as Hale Pōhaku, is a complex of support facilities for the telescopes and other instruments that comprise the Mauna Kea Observatory atop Mauna Kea, on Hawai'i island.

Pacific Tsunami Museum is a museum in Hilo, Hawaii dedicated to the history of the April 1, 1946 Pacific tsunami and the May 23, 1960 Chilean tsunami which devastated much of the east coast of the Big Island, especially Hilo. The museum also has a mission to educate people in general about tsunamis, including the 2004 Indian Ocean earthquake and tsunami. A scientific advisor to the museum has written a book on the two major disasters.

Parker Ranch, in Waimea on Hawaii’s Big Island, was founded in 1847. It is one of the oldest and most historic ranches in the United States. Encompassing across thousands of acres across the island, Parker Ranch is also among the country’s largest cattle ranches.

The Isaacs Art Center is a combination of art museum and retail gallery in Waimea on the Island of Hawaii. The art center’s installation intermixes its own permanent art collection with loans from private collectors and works for sale. The art on display consists primarily of paintings by early and mid twentieth century Hawaii artists. The permanent collection includes about 30 oil paintings and 40 works on paper by Madge Tennent. Other Hawaii artists represented include Jean Charlot, Martha Greenwell, D. Howard Hitchcock, Herb Kawainui Kane, Huc-Mazelet Luquiens, Ben Norris, Louis Pohl, Horatio Nelson Poole, Lloyd Sexton, Jr., and Lionel Walden.

The Kamuela Museum is an entirely privately owned museum. The museum contains a truly eclectic assortment of items collected over the years by the Solomons or passed down from their ancestors, which include the founder of the Parker Ranch. The museum includes six pieces of furniture which were original to the Iolani Palace and which are valued in the millions.

The space center is an educational facility dedicated to the memory of Hawaii’s first astronaut who perished aboard the Challenger Mission in 1986. The Center’s interactive exhibits and videos tell the history of manned space flight, physics and daily life in space.

The observatory is managed by the U.S. Geological Survey, and the National Park Service. Its purpose is to study the activity of Mauna Loa and Kīlauea Volcanoes on a permanent, scientific basis. The Jaggar Museum contains numerous exhibits that explain the history and behavior of Hawaiian volcanoes.

The Observatories at Mauna Kea, (MKO), are an independent collection of astronomical research facilities located on the summit of Mauna Kea on the Big Island of Hawai'i, USA. The facilities are located in a 500-acre (2.0 km2) special land use zone known as the "Astronomy Precinct," which is located in the Mauna Kea Science Reserve. The Astronomy Precinct was established in 1967 and is located on land protected by the Historical Preservation Act for its significance to Hawaiian culture.

The Mokupapapa Discovery Center was constructed to interpret the natural science, culture, and history of the Northwestern Hawaiian Islands and surrounding marine environment. Interactive displays, engaging three-dimensional models, and immersive theater allow the visitor to experience the wonder and majesty of this special ocean region.